ECOFECT


Forum infectiologie du CIRI avec Dr. Fagarasan : “Dynamic interaction between the immune system and bacteria”

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le 19 mars 2015 /

Dans le cadre des Forums d’Infectiologie organisés par le CIRI, le Dr. Sidonia Fagarasan, du Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences (Yokohama, Japon) donnera une conférence intitulée “Dynamic interaction between the immune system and bacteria” le jeudi 19 mars 2015 à 11 h à l’amphithéâtre K sur l’E.N.S. Lyon.

Résumé de la conférence : “Dynamic interaction between the immune system and bacteria”
The main function of the immune system is to protect the host against pathogens, such as bacteria or viruses. However, unlike the systemic immune system, the gut immune system does not eliminate microorganisms but instead nourishes rich bacterial communities and establishes advanced symbiotic relationships. Not only are the gut bacteria essential for nutrient processing, production of vitamins and protection against pathogens (through competition for space and nutrients) but the development and maturation of the immune system depends on these bacteria.
Our previous studies demonstrated that the absence of immunoglobulin A (IgA) (the major effector molecule of the adaptive immunity in the gut), or the impaired IgA selection in germinal centers (GC) due to deregulated T cell control, severely affects the balance of gut bacterial communities, resulting in massive activation of the whole body immune system. Together the results point to an important role played by the adaptive immune system in regulating the microbial communities in the gut. I will discuss our most recent findings of how the adaptive immune system is mediating host-microbial symbiosis, by controlling the diversification and balance of bacterial communities required for gut homeostasis and health.

Pour en savoir plus sur Dr Fagarasan : http://www.riken.jp/en/research/labs/ims/mucos_immun/

Téléchargez l’affiche du forum (.pdf)

Contact : Dominique Kaiserlian, dominique.kaiserlian@inserm.fr